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Patient Case: Lichen Simplex

Discussion

A 42-year-old woman presents with a three-month history of an intensely itchy, thickened patch on the left side of her neck. She reports that the itching is worse at night and that she often finds herself scratching unconsciously, especially during stressful moments. She has tried applying over-the-counter moisturizers, but the itch persists.

She has a history of mild anxiety but no known allergies, eczema, or psoriasis. She denies using new skincare products, and no other areas of her body are affected.

On examination, there is a well-defined, hyperpigmented, leathery plaque with exaggerated skin lines on the lateral side of her neck. No signs of infection, scaling, or oozing are present. A clinical diagnosis of lichen simplex chronicus (neurodermatitis) is made, likely triggered by chronic scratching due to habitual itching.

She is advised to break the itch-scratch cycle with topical corticosteroids, antihistamines, and behavioral modifications. Emollients are recommended to keep the area moisturized, and stress-reduction techniques are discussed to prevent recurrence.

Questions
1. What is the most likely diagnosis in this patient?

a) Atopic dermatitis
b) Lichen simplex chronicus
c) Psoriasis
d) Contact dermatitis

2. What is the primary cause of this condition?

a) Chronic scratching or rubbing
b) Autoimmune skin reaction
c) Bacterial skin infection
d) Exposure to an irritant or allergen

3. What is the most appropriate initial treatment?

a) High-potency topical corticosteroids and antihistamines
b) Systemic immunosuppressants
c) Oral antibiotics and antifungals
d) Daily exfoliation and use of strong moisturizers

4. Which of the following is an effective strategy to prevent recurrence?

a) Identifying and avoiding triggers such as stress or anxiety
b) Applying topical steroids continuously for months
c) Scrubbing the area aggressively to remove thickened skin
d) Using systemic corticosteroids as a long-term solution

Reveal answers

Answers

  1. (b) Lichen simplex chronicus
    • The presence of a well-defined, thickened, leathery plaque with exaggerated skin lines on the neck, along with chronic itching and scratching, is characteristic of lichen simplex chronicus (LSC). Atopic dermatitis (a) usually affects flexural areas and starts in childhood, psoriasis (c) has silvery scales and affects multiple sites, and contact dermatitis (d) has a clear allergic or irritant trigger.
  2. (a) Chronic scratching or rubbing
    • LSC is a reaction to repeated trauma from persistent scratching or rubbing, often triggered by stress or anxiety. Autoimmune reactions (b), bacterial infections (c), and irritant exposure (d) are not primary causes of LSC.
  3. (a) High-potency topical corticosteroids and antihistamines
    • Topical corticosteroids reduce inflammation and itch, while antihistamines help control nighttime itching. Immunosuppressants (b) are unnecessary, antibiotics and antifungals (c) are only needed for infections, and daily exfoliation (d) can worsen the condition.
  4. (a) Identifying and avoiding triggers such as stress or anxiety
    • Preventing recurrence requires breaking the itch-scratch cycle, which includes stress management and behavioral therapy. Continuous steroid use (b) can lead to skin thinning, scrubbing the skin (c) worsens irritation, and systemic steroids (d) are not a long-term solution for this condition.

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