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Patient Case: Juvenile Idiopathic Arthritis

Patient case fields
Patient Background

A 9-year-old child is brought to a community health clinic by their parents due to persistent joint swelling and stiffness, particularly in the knees and wrists, for the past four months. The parents report that the child has difficulty getting out of bed in the morning due to stiffness, which improves slightly after some movement. The child has also been more fatigued than usual and has had occasional low-grade fevers.

Discussion

Medical History & Social Background

The child has no history of previous joint injuries or infections. There is no known family history of autoimmune diseases. The parents initially attributed the symptoms to normal childhood growth pains but became concerned as the swelling persisted. The child attends school but has been struggling to participate in physical activities due to joint pain.

Physical Examination

• Swelling and tenderness in both knees and wrists, with limited range of motion.

• Mild warmth over affected joints but no significant redness.

• No skin rashes, nodules, or other systemic findings.

• No evidence of recent infections or trauma.

Laboratory & Imaging Findings

• Elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP).

• Rheumatoid factor (RF): Negative.

• Anti-nuclear antibodies (ANA): Positive.

• X-ray: Shows periarticular osteopenia but no significant joint erosion.

Diagnosis

Based on the clinical presentation and test results, the child is diagnosed with juvenile idiopathic arthritis (JIA), oligoarticular type.

Management Plan

1. Pharmacologic Treatment

• Non-steroidal anti-inflammatory drugs (NSAIDs) for pain and inflammation.

• Methotrexate for disease-modifying treatment in case of worsening symptoms.

• Close monitoring for uveitis due to positive ANA.

Non-Pharmacologic Treatment

• Referral to a physiotherapist for joint exercises to maintain mobility.

• Parental education on the importance of early treatment and follow-ups.

• School modifications to accommodate physical limitations.

Follow-Up & Monitoring

• Regular ophthalmologic screenings for uveitis.

• Blood tests to monitor inflammation and medication side effects.

• Adjustments to therapy based on disease progression.

Challenges & Considerations

• Limited access to pediatric rheumatologists.

• Financial constraints affecting long-term treatment adherence.

• Need for increased awareness among caregivers and school staff.

Prognosis

With early intervention and appropriate management, the child has a good chance of maintaining joint function and avoiding long-term disability. However, regular monitoring is essential to prevent complications such as uveitis and joint contractures.

Questions
1. What is the most likely diagnosis for this child?

A) Rheumatoid arthritis

B) Septic arthritis

C) Juvenile idiopathic arthritis (JIA)

D) Systemic lupus erythematosus

2. Which of the following findings is most concerning and requires regular monitoring in this patient?

A) Positive anti-nuclear antibodies (ANA)

B) Negative rheumatoid factor (RF)

C) Mild periarticular osteopenia on X-ray

D) Low-grade fever

3. What is the initial pharmacologic treatment recommended for this child’s condition?

A) Methotrexate

B) Non-steroidal anti-inflammatory drugs (NSAIDs)

C) Prednisolone

D) Hydroxychloroquine

4. What is a major long-term complication of juvenile idiopathic arthritis that should be monitored?

A) Osteoporosis

B) Uveitis

C) Pulmonary fibrosis

D) Kidney failure

Reveal answers

Answers

1. (C) Juvenile idiopathic arthritis (JIA)

The child’s chronic joint swelling, morning stiffness, and lack of infection or systemic disease suggest JIA. Septic arthritis would present with acute pain, redness, and fever, while rheumatoid arthritis is primarily an adult condition.

2. (A) Positive antinuclear antibodies (ANA)

ANA positivity is associated with a higher risk of uveitis, a serious eye complication in JIA. Regular ophthalmologic screenings are necessary to prevent vision loss.

3. (B) Non-steroidal anti-inflammatory drugs (NSAIDs)

NSAIDs are the first-line treatment for mild to moderate JIA to reduce pain and inflammation. Methotrexate is reserved for more severe cases or when NSAIDs are insufficient.

4. (B) Uveitis

Uveitis is a silent but serious complication of JIA, particularly in ANA-positive patients. It can lead to vision loss if not detected early, making regular eye exams crucial for long-term management.

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