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Patient Case: Exfoliative Dermatitis

Discussion

A 55-year-old man presents with a two-month history of progressively worsening red, scaly skin that covers most of his body. He reports severe itching, burning, and peeling of the skin, along with episodes of chills and fatigue. The rash initially started on his legs but gradually spread to his trunk, arms, and face. He has also noticed increased hair shedding and thickened, brittle nails.

His medical history includes long-term psoriasis, for which he had been using a high-potency topical corticosteroid. He denies any recent medication changes, infections, or new skincare products.

On examination, nearly 90% of his body surface is covered in diffuse erythema, scaling, and desquamation (skin peeling). His skin feels warm, and there is pitting of the fingernails. No mucosal involvement or signs of infection are noted. His vital signs reveal a mild tachycardia and low-grade fever. A clinical diagnosis of exfoliative dermatitis (erythroderma) is made, likely secondary to psoriasis and prolonged corticosteroid use.

He is admitted for fluid and electrolyte management, given emollients and topical corticosteroids under medical supervision, and started on systemic therapy to address the underlying cause.

Questions
1. What is the most likely diagnosis in this patient?

a) Atopic dermatitis
b) Seborrheic dermatitis
c) Exfoliative dermatitis (erythroderma)
d) Allergic contact dermatitis

2. Which of the following is the most likely trigger for this patient’s condition?

a) Long-term use of high-potency topical corticosteroids
b) Fungal skin infection
c) Exposure to harsh chemicals
d) Deficiency of essential fatty acids

3. What is the most critical initial step in managing this patient?

a) Immediate initiation of systemic corticosteroids
b) Hospital admission for fluid, electrolyte, and skin barrier management
c) Performing a skin biopsy before starting treatment
d) Applying over-the-counter emollients at home and monitoring for improvement

4. Which of the following complications is most concerning in patients with exfoliative dermatitis?

a) Secondary bacterial infections and sepsis
b) Development of acneiform lesions
c) Increased risk of allergic reactions to topical treatments
d) Hyperpigmentation as the primary long-term concern

Reveal answers

Answers

  1. (c) Exfoliative dermatitis (erythroderma)
    • The widespread erythema, scaling, and desquamation covering most of the body, along with itching, systemic symptoms (chills, fatigue, fever), and nail changes, is characteristic of exfoliative dermatitis. Atopic dermatitis (a) usually presents in childhood and involves flexural areas, seborrheic dermatitis (b) primarily affects oily areas with greasy scales, and allergic contact dermatitis (d) is localized and linked to specific triggers.
  2. (a) Long-term use of high-potency topical corticosteroids
    • Prolonged use of high-potency corticosteroids, especially for underlying conditions like psoriasis, can trigger rebound erythroderma when discontinued or lead to systemic absorption effects. Fungal infections (b), chemical exposure (c), and nutrient deficiencies (d) are not the primary causes of exfoliative dermatitis in this case.
  3. (b) Hospital admission for fluid, electrolyte, and skin barrier management
    • Exfoliative dermatitis can lead to severe fluid loss, electrolyte imbalances, and increased risk of infections, requiring hospitalization and supportive care. Systemic corticosteroids (a) are not always the first-line treatment and can worsen conditions like psoriasis. A skin biopsy (c) may be useful but should not delay critical supportive care. At-home emollients (d) are insufficient for managing severe cases.
  4. (a) Secondary bacterial infections and sepsis
    • Patients with exfoliative dermatitis have impaired skin barrier function, making them highly vulnerable to secondary bacterial infections, cellulitis, and even sepsis. Acneiform lesions (b) and allergic reactions (c) are not major complications, and while hyperpigmentation (d) can occur, it is not the most concerning complication.

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