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Patient Case: Cutaneous Manifestations of HIV

Discussion

Chief Complaint: “I have persistent skin rashes and sores that don’t seem to heal.”

History of Present Illness:
A 34-year-old man presents with complaints of multiple skin rashes and non-healing sores over the past three months. He first noticed small red patches on his arms and chest, which later developed into raised, scaly lesions. Some areas have become darker and ulcerated. He also reports occasional itching and burning sensations. Additionally, he has been experiencing unexplained weight loss, night sweats, and chronic fatigue.

The patient recalls having frequent bouts of oral thrush in the past year and a few episodes of prolonged diarrhea. He has not sought medical attention before and denies any known history of chronic illnesses.

Physical Examination:

  • Multiple hyperpigmented, scaly plaques on the chest, arms, and back
  • Non-healing ulcers on the legs and oral mucosa
  • White, thick patches on the tongue and inner cheeks
  • Mild generalized lymphadenopathy
  • No signs of acute systemic infection, but the patient appears thin and fatigued

Diagnosis:
The presence of multiple persistent skin lesions, oral candidiasis, and systemic symptoms raises strong suspicion of HIV infection with cutaneous manifestations. Skin conditions such as seborrheic dermatitis, Kaposi sarcoma, eosinophilic folliculitis, and opportunistic infections (e.g., fungal and bacterial skin infections) are common in individuals with HIV. The history of recurrent oral thrush and unexplained weight loss further supports the need for HIV testing.

Management Plan:

  • HIV Testing and Counseling: Immediate HIV screening and confirmatory testing
  • Treatment for Skin Lesions: Topical and systemic antifungals for oral thrush and possible fungal skin infections; biopsy of any suspicious lesions
  • Antiretroviral Therapy (ART): If HIV is confirmed, initiation of ART to control viral load and improve immune function
  • Supportive Care: Nutritional support, management of secondary infections, and psychological counseling

The patient is scheduled for follow-up with an infectious disease specialist to confirm the diagnosis, assess his immune status (CD4 count and viral load), and begin appropriate treatment.

Questions
  1. What is the most likely underlying condition in this patient?
    a) Chronic eczema
    b) Secondary syphilis
    c) HIV infection with cutaneous manifestations
    d) Systemic lupus erythematosus
  2. Which of the following skin conditions is strongly associated with HIV?
    a) Psoriasis
    b) Kaposi sarcoma
    c) Vitiligo
    d) Contact dermatitis
  3. What is the best initial diagnostic test for this patient?
    a) Skin biopsy
    b) CD4 count
    c) HIV rapid test and ELISA
    d) Complete blood count (CBC)
  4. What is the most important step in managing the patient’s condition?
    a) Prescribing antifungal medications alone
    b) Starting empiric antibiotics for possible bacterial infection
    c) Initiating antiretroviral therapy (ART) if HIV is confirmed
    d) Recommending only topical steroids for the skin lesions
Reveal answers

Answers

  1. (c) HIV infection with cutaneous manifestations – The presence of persistent skin lesions, oral thrush, weight loss, and fatigue strongly suggests an underlying HIV infection. Cutaneous manifestations are common in immunocompromised individuals.
  2. (b) Kaposi sarcoma – Kaposi sarcoma is a vascular tumor associated with HIV/AIDS, caused by human herpesvirus 8 (HHV-8). It often presents as purplish or dark skin lesions and is a key indicator of advanced HIV.
  3. (c) HIV rapid test and ELISA – The most important initial test for suspected HIV is an HIV rapid test followed by ELISA and confirmatory testing (e.g., Western blot or PCR). CD4 count is useful but does not confirm the diagnosis.
  4. (c) Initiating antiretroviral therapy (ART) if HIV is confirmed – The primary treatment for HIV-related skin conditions and systemic symptoms is ART, which helps restore immune function and reduces opportunistic infections, including cutaneous manifestations.

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