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Patient case: Hidradenitis suppurativa

Discussion

A 29-year-old woman presents to the dermatology clinic with a five-year history of painful, recurrent boils in both armpits. The lesions start as small, tender lumps and then progress to large, deep nodules that sometimes rupture and drain foul-smelling pus. Over time, she has noticed scarring and skin thickening in the affected areas.

She reports that the flare-ups worsen before her menstrual cycle and that she has had similar painful bumps in the groin area in the past. She denies any fever but notes difficulty raising her arms due to pain. Her medical history is unremarkable, though her mother had similar skin issues. She smokes regularly and is overweight.

On examination, both axillae show multiple inflamed nodules, draining sinus tracts, and thickened scar tissue. There is no active bacterial infection, but the lesions appear deep and chronic. A diagnosis of hidradenitis suppurativa (HS) is made.

The patient is advised to quit smoking, lose weight, and avoid tight clothing. She is started on topical clindamycin and oral antibiotics (doxycycline) for inflammation control, with consideration for biologic therapy (adalimumab) if symptoms persist. She is educated about long-term management, including lifestyle modifications and early treatment of new flare-ups.

Questions
1. What is the most likely diagnosis in this patient?

a) Hidradenitis suppurativa
b) Folliculitis
c) Cellulitis
d) Cutaneous tuberculosis

2. Which of the following is a common risk factor for hidradenitis suppurativa?

a) Smoking
b) Frequent shaving
c) Excessive sun exposure
d) High dairy intake

3. Which treatment is most appropriate for mild to moderate hidradenitis suppurativa?

a) Topical and oral antibiotics (clindamycin, doxycycline)
b) Surgical excision of the affected area
c) Systemic corticosteroids only
d) Daily application of antifungal cream

4. Which feature helps distinguish hidradenitis suppurativa from common bacterial infections?

a) Presence of sinus tracts and scarring
b) Rapid onset with pus drainage
c) Absence of pain in affected areas
d) Improvement with topical steroids alone

Reveal answers

Answers

  1. (a) Hidradenitis suppurativa
    • This patient has recurrent, painful nodules in the axillae with sinus tracts, scarring, and chronic inflammation, which are characteristic of hidradenitis suppurativa (HS).
    • Folliculitis (b) presents as superficial pustules without deep nodules or scarring.
    • Cellulitis (c) is an acute bacterial infection with diffuse redness and swelling but no sinus tracts.
    • Cutaneous tuberculosis (d) is rare and presents with chronic ulcers or nodules, often in endemic areas.
  2. (a) Smoking
    • Smoking is a major risk factor for HS, as it contributes to inflammation and follicular occlusion.
    • Frequent shaving (b) can irritate the skin but does not directly cause HS.
    • Sun exposure (c) has no known association with HS.
    • High dairy intake (d) is sometimes linked to acne but is not a primary risk factor for HS.
  3. (a) Topical and oral antibiotics (clindamycin, doxycycline)
    • Mild to moderate HS is treated with topical clindamycin and oral antibiotics like doxycycline to reduce inflammation and bacterial colonization.
    • Surgical excision (b) is reserved for severe, chronic cases with extensive sinus tracts.
    • Systemic corticosteroids (c) are not first-line therapy but may be used for severe flares.
    • Antifungal creams (d) are ineffective since HS is not a fungal infection.
  4. (a) Presence of sinus tracts and scarring
    • HS is distinguished by sinus tracts, tunneling, and scarring due to chronic inflammation.
    • Bacterial infections (b) like boils and abscesses may have pus drainage but lack sinus tract formation and recurring nodules.
    • HS is painful (c), unlike some skin conditions like epidermoid cysts.
    • Topical steroids (d) alone do not improve HS and may even worsen symptoms

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