A 28-year-old female presents to the clinic with complaints of intermittent abdominal pain, diarrhea, and weight loss over the past 6 months. She reports the abdominal pain is crampy, located in the lower right quadrant, and often worsens after meals. She has noticed that the diarrhea is frequent, watery, and sometimes associated with mucus. She mentions feeling fatigued and has lost 6 kilograms (about 13 pounds) in the last few months despite no significant change in her diet.

The patient has a history of occasional joint pain in her knees and elbows. She also mentions experiencing episodes of mouth sores (aphthous ulcers) in the past few weeks. There is no history of fever or rectal bleeding. The patient does not smoke and has no known family history of inflammatory bowel disease.

On examination, she appears well-nourished but slightly fatigued. Abdominal examination reveals tenderness in the right lower quadrant with mild rebound tenderness. There is no palpable mass or organomegaly. Rectal examination is unremarkable with no signs of active bleeding.

Laboratory tests reveal mild anemia with low hemoglobin (11.5 g/dL), elevated C-reactive protein (CRP), and normal white blood cell count. A stool test is negative for infectious pathogens, and liver function tests are within normal limits.

A colonoscopy with biopsy shows segmental inflammation in the ileum, with cobblestone appearance and strictures. Biopsy reveals granulomas, which are characteristic of Crohn’s disease.

Diagnosis: Crohn’s disease (intestinal form).