Histoplasmosis in darker-skinned individuals typically presents as respiratory symptoms like cough, fever, and fatigue, with skin lesions that can appear as red or purple nodules, which may be more difficult to identify due to skin pigmentation. This fungal infection is caused by Histoplasma capsulatum and is commonly associated with exposure to contaminated soil, particularly in regions with a history of bird or bat droppings. Treatment involves antifungal medications such as itraconazole or amphotericin B, with more severe cases requiring prolonged therapy and close monitoring for systemic involvement.