Guinea worm disease, caused by Dracunculus medinensis, is prevalent in some parts of Sub-Saharan Africa, particularly in remote rural areas with limited access to clean water. The parasitic infection occurs when people drink water contaminated with Guinea worm larvae, leading to painful blisters as adult worms emerge through the skin. Treatment involves carefully extracting the worm over several days, combined with wound care and preventing further contamination of water sources, while eradication efforts focus on improving access to safe drinking water and health education.