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Fixed Drug Eruption (FDE)
Fixed drug eruptions in darker-skinned individuals typically present as dark, violaceous, or slate-gray patches, often with central blistering, which may leave significant post-inflammatory hyperpigmentation. These lesions reappear in the same location each time the offending drug is taken. Treatment involves discontinuing the triggering medication, using topical corticosteroids to reduce inflammation, and addressing hyperpigmentation with lightening agents if needed.
The trunk of a young boy with generalized fixed drug eruption Fixed drug eruption at a dermatology clinic in Lagos, Nigeri... : Journal of Clinical Sciences (lww.com)
Erythema and blisters in acute fixed drug eruptions Fixed drug eruption at a dermatology clinic in Lagos, Nigeri... : Journal of Clinical Sciences (lww.com) (108)
Perioral fixed drug eruption
Recurrent localized FDE. Hyperpigmented patch with surrounding violaceous erythema https://basicmedicalkey.com/fixed-drug-eruptions/
Adult with multiple FDE due to a Cephalosporin https://basicmedicalkey.com/fixed-drug-eruptions/
FDE involving the bilateral hands https://basicmedicalkey.com/fixed-drug-eruptions/
Oral FDE due to Ibuprofen, involving the dorsal tongue https://basicmedicalkey.com/fixed-drug-eruptions/
FDE involving the labia majora, extending down the bilateral inner thighs and perineal area https://basicmedicalkey.com/fixed-drug-eruptions/
FDE due to sulfamethoxazole/trimethoprim, involving the penile shaft https://basicmedicalkey.com/fixed-drug-eruptions/
- Ayanlowo OO. Fixed drug eruption at a dermatology clinic in Lagos, Nigeria. 2015 Jul–Dec .;12(2):108-112.
- Basicmedical Key. Fixed-drug-eruptions. Available at: https://basicmedicalkey.com/fixed-drug-eruptions/. Accessed -02-17, 2024.
- Patel S, John AM, Handler MZ, Schwartz RA. Fixed drug eruptions: an update, emphasizing the potentially lethal generalized bullous fixed drug eruption. American Journal of Clinical Dermatology. 2020 Jun;21:393-9.
