Cytomegalovirus (CMV) infections in darker-skinned individuals can present with a variety of symptoms, including fever, fatigue, and skin manifestations such as purple or reddish spots, which might be harder to detect due to darker skin tones. It is especially concerning in immunocompromised individuals, where it can lead to more severe complications, including retinitis and gastrointestinal involvement. Treatment primarily involves antiviral medications such as ganciclovir or valganciclovir to control the infection and prevent further complications, with supportive care to manage symptoms.