Mycosis fungoides is a rare type of cutaneous T-cell lymphoma that primarily affects the skin, presenting as persistent patches, plaques, or tumors that can be mistaken for chronic dermatitis or eczema. Though uncommon, cases in Sub-Saharan Africa are often diagnosed late due to limited access to dermatopathology services and low clinical awareness. Early detection is crucial, as timely treatment can control symptoms and prevent disease progression. Strengthening diagnostic capacity, clinician training, and public awareness can significantly improve outcomes for patients affected by mycosis fungoides in the region.