Kaposi’s Sarcoma (KS) is a cancer caused by Human Herpesvirus 8 (HHV-8) that commonly affects the skin, lymph nodes, and internal organs. In Sub-Saharan Africa, it remains one of the most prevalent HIV-associated malignancies due to high rates of both HHV-8 and HIV infections. KS often appears as purple or dark lesions on the skin and mucous membranes but can progress rapidly without timely treatment. Early diagnosis, antiretroviral therapy (ART), and access to cancer care are critical to improving survival rates. Strengthening HIV management and oncologic services across the region can greatly reduce the burden of Kaposi’s Sarcoma.