Human Papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide and a leading cause of cervical cancer, particularly among women in Sub-Saharan Africa. With limited access to routine screening and vaccination, HPV continues to drive high rates of preventable cancers across the region. The virus affects both men and women, causing genital warts and several types of anogenital and oropharyngeal cancers. Early detection, HPV vaccination, and improved sexual health education are key strategies to curb its impact. Strengthening public health programs focused on HPV prevention can save countless lives and promote long-term community health.