Bullous diseases are a group of rare skin disorders characterized by blister formation resulting from immune or genetic abnormalities that weaken the connections between skin layers. In Sub-Saharan Africa, early recognition and management of bullous diseases such as pemphigus vulgaris and bullous pemphigoid are essential to prevent severe infections and complications due to limited dermatological resources. Enhancing awareness among medical practitioners about diagnosis, treatment options, and patient education can greatly improve outcomes and reduce morbidity. Strengthening healthcare systems to support dermatological care remains vital for managing these complex skin conditions across the region.