Bacillary (epithelioid) angiomatosis is a rare bacterial infection caused by Bartonella henselae or Bartonella quintana, primarily affecting individuals with weakened immune systems, such as those living with HIV/AIDS. In Sub-Saharan Africa, where immunosuppression and limited access to advanced healthcare remain challenges, recognizing this condition is critical. The disease often manifests as red to purple vascular skin lesions that may resemble Kaposi’s sarcoma, making clinical awareness vital for accurate diagnosis. With timely antibiotic treatment, patients can experience complete recovery. Enhancing medical knowledge of bacillary angiomatosis supports improved dermatologic and infectious disease management across African healthcare systems.