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Patient case: Human Monkeypox

Discussion

A 29-year-old male presents to the clinic with a five-day history of fever, chills, muscle aches, and swollen lymph nodes. Two days after the fever began, he developed a rash that started on his face and spread to his arms, trunk, and legs. The rash initially appeared as flat red spots, which later turned into fluid-filled vesicles and then pustules. He reports no recent illness but mentions close contact with a friend who had similar symptoms a week ago.

On examination, he has a temperature of 38.7°C (101.7°F) and multiple firm, tender lymph nodes in the cervical and axillary regions. His skin shows numerous pustular lesions, some with central umbilication. No lesions are found inside his mouth.

Laboratory tests, including PCR from skin lesion swabs, confirm Monkeypox virus infection. He is advised to isolate at home, manage symptoms with supportive care, and monitor for complications. His condition remains stable, and after three weeks, the lesions scab over and heal without scarring

Questions
1. What is the most likely diagnosis in this patient?

a) Chickenpox

b) Monkeypox

c) Measles

d) Hand, foot, and mouth disease

2. What is a distinguishing feature of monkeypox compared to chickenpox?

a) Monkeypox lesions appear in crops, while chickenpox lesions are in the same stage.

b) Monkeypox lesions progress through uniform stages, while chickenpox lesions appear in different stages.

c) Monkeypox lesions remain confined to the trunk, while chickenpox affects the extremities more.

d) Monkeypox is always asymptomatic, while chickenpox causes severe illness.

3. What is the most appropriate management for this patient?

a) High-dose antiviral therapy

b) Supportive care and isolation

c) Immediate hospitalization for IV antibiotics

d) Corticosteroids and antihistamines

4. How is monkeypox primarily transmitted between humans?

a) Contaminated water and food

b) Mosquito bites

c) Respiratory droplets and direct contact with lesions

d) Airborne transmission only

Reveal answers

Answers

1. Answer: b) Monkeypox

The presence of fever, swollen lymph nodes, and a progressing pustular rash with central umbilication strongly suggests monkeypox. Chickenpox presents with different-stage lesions, and measles causes a maculopapular rash without vesicles.

2. Answer: b) Monkeypox lesions progress through uniform stages, while chickenpox lesions appear in different stages

A key distinguishing factor is that monkeypox lesions evolve synchronously (all lesions are at the same stage), whereas chickenpox lesions appear in various stages at the same time.

3. Answer: b) Supportive care and isolation

There is no specific antiviral treatment for mild monkeypox cases. Management involves symptom relief, hydration, and preventing the spread by isolating until lesions fully heal.

4. Answer: c) Respiratory droplets and direct contact with lesions

Monkeypox spreads through close contact with infected individuals, including respiratory droplets, bodily fluids, and contaminated objects, but it is not primarily airborne like measles or COVID-19

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