Polypharmacy in the elderly in sub-Saharan Africa is a growing concern, driven by the increasing prevalence of chronic diseases such as hypertension, diabetes, and arthritis. Many older adults are prescribed multiple medications to manage these conditions, leading to an elevated risk of drug interactions, adverse effects, prescribing cascades, and decreased medication adherence. Limited access to healthcare resources and inadequate medication management practices further complicates the issue, often resulting in unmonitored polypharmacy. Additionally, cultural beliefs and reliance on traditional medicine can lead to further complications, as herbal remedies may interact with prescribed medications. Addressing polypharmacy requires a comprehensive approach that includes improved healthcare access, regular medication reviews, and education for both healthcare providers and patients on the risks of unnecessary medications.

Geriatric pharmacology in sub-Saharan Africa is an emerging concern, as the region experiences a growing aging population that often faces multiple chronic conditions requiring complex medication regimens. Older adults are particularly vulnerable to polypharmacy, which increases the risk of adverse drug reactions, drug interactions, and medication non-adherence due to a lack of accessible healthcare resources and limited geriatric training among healthcare providers. Additionally, cultural beliefs and socioeconomic factors can influence medication management and access to essential drugs. There is a pressing need for research focused on the pharmacokinetics and pharmacodynamics of medications in this demographic, as many clinical studies do not adequately represent elderly populations. Efforts to improve pharmacological care for the elderly include developing guidelines tailored to their specific needs, enhancing healthcare provider training, and increasing access to affordable medications.

It is common for elderly patients to be prescribed multiple medications. It is important to always ask about drug history including prescribed and over-the-counter medications. Do not forget about alternative/traditional medications which is common in Africa. There is need to continuously review the indication for the drugs now. Follow-up of prescribed drugs.