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Loiasis

Background

Loiasis (African eyeworm), caused by the filarial parasite Loa loa transmitted by deer flies of the Chrysops genus predominant in the rainforest of Central and West Africa. It presents with episodic swelling known as Calabar swellings, which may be less visually prominent but still painful in darker-skinned individuals. The adult worms can sometimes be seen migrating across the eye, causing irritation but usually not blindness. Treatment typically includes diethylcarbamazine (DEC) to kill the adult worms, and in some cases, albendazole is used to manage severe infections, with careful monitoring to prevent complications.

Lesion image

Loa Loa – CSP (schisto.com)  

https://www.sciencedirect.com/science/article/abs/pii/B9780323555128001150

References
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  • Boussinesq M. Loiasis. Annals of Tropical Medicine & Parasitology. 2006 Dec 1;100(8):715-31.
  • World Health Organization. Expanded Special Project for Elimination of Neglected Tropical Diseases. Loaisis. Available at: https://espen.afro.who.int/diseases/loiasis Accessed January 2025.
  • Padgett JJ, Jacobsen KH. Loiasis: African eye worm. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2008 Oct 1;102(10):983-9.
  • Klion AD, Horton J, Nutman TB. Albendazole therapy for loiasis refractory to diethylcarbamazine treatment. Clin Infect Dis. 1999 Sep;29(3):680-2. doi: 10.1086/598654. PMID: 10530467.
  • Loa Loa. 2016; Available at: https://schisto.com/partners/neglected-tropical-diseases/loa-loa/. Accessed 015, 2024.
  • Joseph Kamgno, Amy D. Klion, 115 – Loiasis, Editor(s): Edward T. Ryan, David R. Hill, Tom Solomon, Naomi E. Aronson, Timothy P. Endy, Hunter’s Tropical Medicine and Emerging Infectious Diseases (Tenth Edition), Elsevier, 2020, Pages 859-863, ISBN 9780323555128, https://doi.org/10.1016/B978-0-323-55512-8.00115-0. (https://www.sciencedirect.com/science/article/pii/B9780323555128001150)