Gastrointestinal Stromal Tumour (GIST)
A 47-year-old woman presents with vague abdominal discomfort and bloating that has persisted for several months. She also reports intermittent nausea, early satiety, and occasional vomiting. Over the past two months, she has noticed a gradual decline in her appetite and has unintentionally lost 5 kg. There is no history of significant gastrointestinal bleeding, but she mentions feeling more fatigued than usual.
On physical examination, mild tenderness is noted in the upper abdomen, but no palpable masses are detected. Laboratory tests reveal mild anemia, while other blood work is within normal limits.
An abdominal CT scan shows a well-defined mass in the stomach, measuring approximately 8 cm, with no evidence of metastasis. An endoscopic biopsy is performed, and histopathology confirms the diagnosis of gastrointestinal stromal tumour (GIST), with immunohistochemical staining positive for CD117 (c-KIT).
The patient is referred to an oncologist, and treatment with targeted therapy (imatinib) is initiated, given the tumor size and risk of recurrence. Surgical resection is also considered as part of the treatment plan.
a). Severe abdominal pain and diarrhea
b). Abdominal discomfort, bloating, and early satiety
c). Persistent diarrhea and rectal bleeding
d). Frequent heartburn and acid reflux
a). Liver metastasis
b). A well-defined mass in the stomach
c). Pancreatic enlargement
d). Intestinal obstruction
a). Gastric adenocarcinoma
b). Gastrointestinal stromal tumor (GIST)
c). Colorectal cancer
d). Lymphoma
a). Chemotherapy
b). Radiation therapy
c). Targeted therapy with imatinib
d). Immunotherapy
